Single-use technologies have become an important standard in biopharmaceutics. The Proline Promass U 500 Coriolis flowmeter from Endress+Hauser is designed for exactly these applications. Accuracy, precision, and traceable calibration are at the top of the list of requirements, followed by simple handling and a clear user interface.

There is a strong trend to spot in life sciences: Just as research and development are relying on smaller, more dynamic and flexible processes, the production of biopharmaceutical products is also becoming more agile, diversified and, as a result, usually smaller in scale.

Single-use bioreactors have long been the standard in upstream applications and are perhaps the most important prospects for downstream processes in growth markets such as monoclonal antibodies, mRNA-based active ingredients or cell and gene therapies.

In ideal cases, the instrumentation of the facilities will be able to help this development along. The Promass U 500 from Endress+Hauser is a Coriolis flowmeter which has the potential to progress the technological maturity of single-use applications on the side of measuring technology.

High-level measuring performance thanks to Coriolis technology and material selection

Promass U 500 consists of a base unit which contains the components for the power supply, exciter, and sensors, as well as other electronics. This base unit is available in two versions: The first is an installed version which OEM manufacturers can integrate into their platforms.

For flexible laboratory applications, a table-top version is also available in its own housing with the corresponding connections to the local working environment. The two versions do not differ in terms of function. The disposable component is inserted into the base unit.

To cover a large range of applications, the disposable component is offered in four different nominal diameters: DN 4 (⅛"), DN 6 (¼"), DN 15 (½") and DN 25 (1"). It is also designed to be self-drainable, which makes handling easier for disposal.

The technical data specifies flow rates of 0.12 to 75 l/min. A special feature of Promass U 500 is its ability to cover a wide range of flow rates with one nominal diameter, without compromising on measuring accuracy.

This is 0.5% of mass flow, which is a value never before reached in single-use applications. With the high price of many biopharmaceuticals, measurement inaccuracies can quickly lead to economic disadvantages.

Proline Promass U 500 offers full cGMP compliance, in particular during the calibration, and high-level measuring performance for flow, temperature and density.

At the same time, the flowmeter reduces handling and documentation effort for the end user. Heartbeat Technology plays a key role in diagnostics, verification and monitoring here. This makes the device equally interesting for OEM manufacturers of single-use platforms in biotechnology as well as lab users who also want to leverage the potential of innovative, cost-efficient single-use systems in downstream processes.

In addition, Promass U 500 from Endress-Hauser is a forward-looking component of the digital transformation of biotechnology.  

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