Chromatography has become a cornerstone of modern analytical science, supporting breakthroughs in pharmaceuticals, biotechnology, environmental monitoring, petrochemical analysis and countless industrial research applications.

As analytical challenges grow more complex – requiring faster processing, higher sensitivity and uncompromising reproducibility – instrument manufacturers face the need for equally advanced control technologies that guarantee stability throughout the entire analytical workflow.

SMC stands at the forefront of this evolution. With more than 700,000 automation and fluid-control components available worldwide, we deliver one of the most extensive, reliable and technically advanced product ecosystems in the industry.

Enhance accuracy and long-term performance

Our solutions, ranging from high-precision pneumatic systems to advanced microfluidics, high-purity gas and liquid handling, vacuum technology and custom-designed manifolds, are engineered to enhance the accuracy and long-term performance of chromatographic instruments.

SMC solutions bring together a wide range of technologies designed to ensure optimal performance across all chromatographic systems. Each component is engineered to meet the demanding requirements of modern analytical instruments, providing precise gas and liquid management as well as stable control of pressure, flow and vacuum.

Our portfolio includes high-purity valves, precision regulators, dispense pumps, filters, air dryers, sensors, chemical-resistant tubing and a wide selection of auxiliary components that enable instrument manufacturers to design equipment that is more reliable, compact and efficient.

Whether used in Liquid Chromatography (LC), Gas Chromatography (GC), or Mass Spectrometry (MS), SMC products deliver stability, chemical compatibility, low particle generation and seamless integration into complex architectures.

This lineup not only represents individual components but also a complete solution designed to enhance analytical repeatability, reduce maintenance requirements and optimise the end-user experience. Combining innovation, quality and global availability, SMC provides a comprehensive range of products that cover every critical stage of the chromatographic process – ensuring every instrument performs with the highest levels of precision and reliability.

Liquid chromatography demands precise and stable management of liquids, gases and thermal conditions. Fluctuations in flow, pressure or temperature can significantly impact resolution, peak shape, detection limits and overall reproducibility.

Components engineered specifically

To meet these demanding requirements, SMC provides an extensive suite of components engineered specifically for the challenges of liquid chromatography. Our isolated-structure valves ensure chemically inert, contamination-free flow paths suitable for aggressive mobile phases and organic solvents. Their metal-free, oil-free architecture and diaphragm isolation minimise heat transfer and prevent unwanted chemical interaction, guaranteeing stable operation even during prolonged analytical cycles.

Complementing these valves, SMC’s solenoid driven dispense pumps deliver microlitre-level dosing precision for rinsing, auto-sampling and reagent delivery – with repeatability as tight as ±1 %, ensuring reliable sample preparation and consistent injection conditions.

Beyond fluid control, SMC supports advanced LC system automation through electric actuators with integrated controllers and compact grippers. These solutions enable precise, repeatable positioning and handling in autosamplers, vial transfer mechanisms, fraction collectors and sample preparation modules, while simplifying system architecture and reducing wiring and control complexity.

Whether for autosampler control, solvent delivery, waste separation, precise mobile-phase switching, automated handling, thermal regulation or detector support, SMC delivers a comprehensive range of solutions that cover every stage of the LC workflow – from sample introduction to detection and fraction collection